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Nicola Margiotta Selected Research

1,2-cyclohexanediamine (dach)

6/2022Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration.
6/2016Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position.
8/2012Revisiting [PtClâ‚‚(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.
2/2010Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring Pt II chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.
4/2008Conformer distribution in (cis-1,4-DACH)bis(guanosine-5'-phosphate)platinum(II) adducts: a reliable model for DNA adducts of antitumoral cisplatin.

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Nicola Margiotta Research Topics

Disease

29Neoplasms (Cancer)
06/2022 - 08/2004
7Neoplasm Metastasis (Metastasis)
01/2020 - 08/2007
6Colonic Neoplasms (Colon Cancer)
01/2017 - 08/2012
5Colorectal Neoplasms (Colorectal Cancer)
06/2022 - 08/2012
3Breast Neoplasms (Breast Cancer)
07/2020 - 06/2016
3Glioma (Gliomas)
11/2014 - 07/2010
2Lewis Lung Carcinoma
06/2022 - 04/2021
2Glioblastoma (Glioblastoma Multiforme)
06/2020 - 06/2016
2Bites and Stings (Sting)
02/2015 - 04/2008
2Neurodegenerative Diseases (Neurodegenerative Disease)
11/2014 - 06/2014
1Ovarian Neoplasms (Ovarian Cancer)
01/2022
1Necrosis
06/2021
1Body Weight (Weight, Body)
04/2021
1Uterine Cervical Neoplasms (Cancer of the Cervix)
03/2020
1Carcinoma (Carcinomatosis)
10/2019
1Bone Diseases (Bone Disease)
07/2019
1Neuroblastoma
11/2018
1Bone Neoplasms (Bone Cancer)
04/2017
1Prostatic Neoplasms (Prostate Cancer)
07/2016
1Rectal Neoplasms (Rectal Cancer)
01/2016
1Hepatocellular Carcinoma (Hepatoma)
08/2012
1Osteosarcoma (Osteogenic Sarcoma)
01/2012
1Lung Neoplasms (Lung Cancer)
01/2012
1Mesothelioma
04/2011
1Malignant Mesothelioma
04/2011
1Metabolic Bone Diseases (Osteopenia)
04/2011

Drug/Important Bio-Agent (IBA)

16LigandsIBA
06/2022 - 08/2004
14Oxaliplatin (Eloxatin)FDA LinkGeneric
06/2022 - 08/2012
13Cisplatin (Platino)FDA LinkGeneric
06/2022 - 12/2005
13PlatinumIBA
11/2021 - 08/2007
11platinum(II)(1,4- diazacycloheptane)dichlorideIBA
06/2022 - 09/2014
6Pharmaceutical PreparationsIBA
06/2022 - 01/2012
51,2-cyclohexanediamine (dach)IBA
06/2022 - 04/2008
4DiaminesIBA
06/2022 - 04/2008
4Diphosphonates (Bisphosphonates)IBA
04/2017 - 04/2011
3Benzoates (Benzoate)IBA
06/2022 - 01/2016
3ProdrugsIBA
06/2022 - 03/2020
3Durapatite (Hydroxylapatite)IBA
01/2021 - 12/2012
3Proteins (Proteins, Gene)FDA Link
07/2016 - 06/2014
3Antineoplastic Agents (Antineoplastics)IBA
09/2014 - 08/2012
2Selenious Acid (Selenite)IBA
01/2021 - 01/2020
2IonsIBA
01/2021 - 07/2020
2SeleniumIBA
01/2021 - 01/2020
2diphosphoric acid (pyrophosphoric acid)IBA
10/2017 - 04/2011
2NitrogenIBA
02/2015 - 04/2011
2DNA (Deoxyribonucleic Acid)IBA
06/2014 - 02/2010
11,4-diaminocyclohexaneIBA
06/2021
1CyclohexaneIBA
04/2021
1CarbonIBA
04/2021
1Citric Acid (Citrate)FDA LinkGeneric
07/2020
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
06/2020
1Lipid NanoparticlesIBA
06/2020
1cyclohexeneIBA
03/2020
1Biocompatible Materials (Biomaterials)IBA
01/2020
1A-factor (Streptomyces)IBA
01/2020
1PhenanthrolinesIBA
11/2018
1neocuproineIBA
11/2018
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
05/2018
1pyridineIBA
07/2016
1Acetates (Acetic Acid Esters)FDA Link
06/2016
1Protons (Proton)IBA
02/2015
1Coordination ComplexesIBA
11/2014
1AminesIBA
09/2014
1Growth InhibitorsIBA
06/2014
1Silicon Dioxide (Silica)FDA LinkGeneric
12/2012
1Polymethyl Methacrylate (Sol)IBA
12/2012
1CalciumIBA
12/2012
1ApatitesIBA
01/2012
1GABA-A Receptors (GABA(A) Receptor)IBA
07/2010
1DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
02/2010
1DNA AdductsIBA
02/2010
1Glutathione (Reduced Glutathione)IBA
02/2010

Therapy/Procedure

3Drug Therapy (Chemotherapy)
01/2020 - 08/2012
2Therapeutics
01/2021 - 07/2016
1Intraperitoneal Injections
06/2022
1Oral Administration
06/2022
1Radiotherapy
04/2017
1Palliative Care (Palliative Therapy)
04/2017